Finally steps in escort aptamer preparing cover synthetic modifications of the truncated aptamer

Finally steps in escort aptamer preparing cover synthetic modifications of the truncated aptamer Further nuclease stabilization is achieved by substitution of 2?-OCHstep three for 2?-OH at purine positions. As the 2?-OCH3 moiety is not compatible with current SELEX process enzymes, this alteration must occur during chemical synthesis following evolution of a specific aptamer sequence. Generally, [